Hypoglycemia linked to reduction in low-frequency component of heart rate variability in type 1 diabetes. According to a study ,HealthDay News — For adults with type 1 diabetes there is a marked decrease in the low-frequency component of heart rate variability during spontaneous nocturnal hypoglycemia.

Minna L. Koivikko studies shows ,adults with type 1 diabetes after having continuous glucose monitoring via a subcutaneous sensor for three nights. During periods of hypoglycemia and during a control nonhypoglycemic period) of equal duration at the same time of night, heart rate variability was analyzed.

The researchers found that hypoglycemic and control episodes lasted of 71 minutes. The heart rate or the high-frequency component of heart rate power spectrum did not change significantly during hypoglycemia.

Significant decrease seen in the low-frequency component of heart rate variability seen with hypoglycemia. There was a significant positive association between the decline in the glucose concentration and the decrease of the low-frequency component of heart rate .During controlled sympathetic activation, the decrease in the low-frequency component of heart rate variability was closely related to an increase in muscle sympathetic nerve action recorded in 10 subjects.

Spontaneous nocturnal hypoglycemia in patients with type 1 diabetes results in a reduction of the low-frequency component of heart rate, which is best explained by excessive sympathetic activation without a concomitant withdrawal of vagal outflow.

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